Insights into the Effect of Trigonelline in the P53 Pathway
ثبت نشده
چکیده
منابع مشابه
Effect of 4 weeks of High-Intensity Interval Training on P53 and Caspase-3 Proteins Content in the Heart Muscle Tissue of Rats with Type 1 Diabetes
Introduction: Type 1 diabetes can lead to muscle apoptosis and a defect in the structure of the heart tissue. One of the main pathways of apoptosis is the pathway activated by the P53 and Caspase-3 proteins. Therefore, the aim of this study was to investigate the effect of 4 weeks of high intensity interval training on the content of P53 and Caspase-3 proteins in heart muscle tissue of Sprague-...
متن کاملThe Effect of Ampk and P53 Proteins On Tor Pathway Following Endurance Training In The Left Ventricle Of The Heart Of Diabetic Rats By Streptozotocin And Nicotinamide
Background: AMPK and P53 proteins regulate the TOR protein in the TORC1 complex, which regulates many physiological processes. The aim of this study was to evaluate the effect of AMPK and P53 proteins on the TOR pathway following endurance training in the left ventricle of the heart of diabetic rats by streptozotocin and nicotinamide. Methods: In this experimental study, 12 head two-month-old ...
متن کاملMatrine inhibits diethylnitrosamine-induced HCC proliferation in rats through inducing apoptosis via p53, Bax-dependent caspase-3 activation pathway and down-regulating MLCK overexpression
The proliferation of hepatocellular carcinoma (HCC) cells is one of the leading causes of liver cancer mortality in humans. The inhibiting effects of matrine on HCC cell proliferation have been studied, but the mechanism of that inhibition has not been fully elucidated. Since, apoptosis plays an important role in HCC cell proliferation. We examined the apoptosis-inducing effect of matrine on tu...
متن کاملMatrine inhibits diethylnitrosamine-induced HCC proliferation in rats through inducing apoptosis via p53, Bax-dependent caspase-3 activation pathway and down-regulating MLCK overexpression
The proliferation of hepatocellular carcinoma (HCC) cells is one of the leading causes of liver cancer mortality in humans. The inhibiting effects of matrine on HCC cell proliferation have been studied, but the mechanism of that inhibition has not been fully elucidated. Since, apoptosis plays an important role in HCC cell proliferation. We examined the apoptosis-inducing effect of matrine on tu...
متن کاملEffect of Trigonelline on Dendritic Morphology in the Hippocampus and Prefrontal Cortex in Streptozotocin-Induced Diabetic Rats
Introduction: Diabetes mellitus causes adverse changes in the neurological morphology of the hippocampus and prefrontal cortex of the brain by increasing oxidative stress. Trigonelline has antihyperglycemic effects and can inhibit oxidative stress. The aim of this study was to evaluate the protective effect of trigonelline on dendritic changes in hippocampal and prefrontal cortex neurons in dia...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2014